Structure
(Vornorexant, CAS 1517965-94-4)
Alisertib sodium Biochemical
Alisertib sodium
Purity
98%
Synonyms
Alisertib sodium; N/A; ORN-0829; TS-142; Alisertib sodium biochemical
Purity/Purification
98%
CAS
1028486-06-7
Targets&IC50
Aurora A:12.5 nM (IC50), Aurora B:396.5 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Alisertib (MLN 8237)(30 mg/kg, p.o.) significantly reduces tumor burden and increases overall survival in xenograft-murine model of human-MM[1]. Alisertib (3-30 mg/kg; P.o.; once daily for 3 weeks) causes tumor growth inhibition in solid tumor xenograft models[4]. Animal Model: Nude mice bearing HCT-116 colon tumor xenograft[4]. Dosage: 3, 10, or 30 mg/kg. Administration: P.o.; once daily for 3 weeks. Result: Resulted in a dose-dependent TGI (tumor growth inhibition) of 43.3%, 84.2%, and 94.7% for the 3, 10, and 30 mg/kg groups,respectively.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Vornorexant, CAS 1517965-94-4)
Structure
(Vornorexant, CAS 1517965-94-4)
Structure
(Vornorexant, CAS 1517965-94-4)
Structure
(Vornorexant, CAS 1517965-94-4)
Related Product Information for Alisertib sodium biochemical
Alisertib (MLN 8237) sodium is an orally active and selective Aurora A kinase inhibitor (IC 50 =1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.
References
1. Aya Futamura, et al. Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Bioorg Med Chem. 2020 Jul 1;28(13):115489.
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Product Notes
The Alisertib sodium (Catalog #AAA227425) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Alisertib sodium, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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