Structure
(Propenyl-PEG3-Propenyl, CAS 90736-68-8)
Mipomersen sodium Biochemical
Mipomersen sodium
Purity
98%
Synonyms
Mipomersen sodium; N/A; Triethylene glycol diallyl ether; Mipomersen sodium biochemical
Purity/Purification
98%
CAS
629167-92-6
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2]. Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Propenyl-PEG3-Propenyl, CAS 90736-68-8)
Structure
(Propenyl-PEG3-Propenyl, CAS 90736-68-8)
Structure
(Propenyl-PEG3-Propenyl, CAS 90736-68-8)
Structure
(Propenyl-PEG3-Propenyl, CAS 90736-68-8)
Related Product Information for Mipomersen sodium biochemical
Mipomersen (sodium) is a second-generation 20-base phosphorothioate ASO targeted to human apoB-100.
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The Mipomersen sodium (Catalog #AAA228815) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Mipomersen sodium, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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