Structure
(FP-Biotin, CAS 259270-28-5)
BCR-ABL-IN-3 biochemical
BCR-ABL-IN-3
Purity
98%
Synonyms
BCR-ABL-IN-3; N/A; BCR-ABL-IN-3 biochemical
Purity/Purification
98%
CAS
2240191-12-0
Targets&IC50
Ba/F 3 Bcr-Abl T3151:<=100 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
BCR-ABL-IN-3 (compound 7; 15 mg/kg; twice a day; for 19 days) has good antitumor effect in female NOD/SCID mice of 7-8 weeks weighing 21.8 g with Ba/F 3 Bcr-Abl T3151 cells[1]. BCR-ABL-IN-3 (2 mg/kg for IV or 20mg/kg for PO) has a C max of 5485 ng/mL and an AUC of 5450 h/ng/mL for IV in male Sprague Dawley rats of 7-8 weeks old weighing 210 g[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(FP-Biotin, CAS 259270-28-5)
Structure
(FP-Biotin, CAS 259270-28-5)
Structure
(FP-Biotin, CAS 259270-28-5)
Structure
(FP-Biotin, CAS 259270-28-5)
Related Product Information for BCR-ABL-IN-3 biochemical
BCR-ABL-IN-3 is a potent and irreversible Bcr-Abl inhibitor with an IC 50 of <=100 nM for Ba/F 3 Bcr-Abl T3151. BCR-ABL-IN-3 has anti-cancer activity.
References
1. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754.
2. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861.
3. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.
2. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861.
3. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.
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Product Notes
The BCR-ABL-IN-3 (Catalog #AAA228238) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BCR-ABL-IN-3, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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