Structure
(Cantrixil, CAS 2135511-22-5)
BMSpep-57 biochemical
BMSpep-57
Purity
98%
Synonyms
BMSpep-57; N/A; TRX-E-002-1; BMSpep-57 biochemical
Purity/Purification
98%
CAS
1629655-80-6
Targets&IC50
PD-1/PD-L1 interaction:7.68?nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC 50 of 7.68nM[1]. BMSpep-57 induced high levels of IL-2 at 1uM and 500nM concentrations in SEB-stimulated peripheral blood mononuclear cells[1]. BMSpep-57 (0.2-10 uM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells' viability at the various concentrations tested[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Cantrixil, CAS 2135511-22-5)
Structure
(Cantrixil, CAS 2135511-22-5)
Structure
(Cantrixil, CAS 2135511-22-5)
Structure
(Cantrixil, CAS 2135511-22-5)
Related Product Information for BMSpep-57 biochemical
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC 50 of 7.68 nM. BMSpep-57 binds to PD-L1 with K d s of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.
References
1. Muhammad Wasif Saif, et al. Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1). Cancer Chemother Pharmacol. 2017 Feb;79(2):303-314.
2. Ayesha B Alvero, et al. TRX-E-002-1 Induces c-Jun-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo. Mol Cancer Ther. 2016 Jun;15(6):1279-90.
2. Ayesha B Alvero, et al. TRX-E-002-1 Induces c-Jun-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo. Mol Cancer Ther. 2016 Jun;15(6):1279-90.
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Product Notes
The BMSpep-57 (Catalog #AAA227834) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMSpep-57, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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