Structure
((Z)-PUGNAc, CAS 132489-69-1)
C2 Phytoceramide (t18:0/2:0) Biochemical
C2 Phytoceramide (t18:0/2:0)
Purity
98%
Synonyms
C2 Phytoceramide (t18:0/2:0); N/A; C2 Phytoceramide (t18:0/2:0) biochemical
Purity/Purification
98%
Solubility
Ethanol: Soluble
Methanol: Soluble
DMSO: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
Methanol: Soluble
DMSO: Soluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
((Z)-PUGNAc, CAS 132489-69-1)
Structure
((Z)-PUGNAc, CAS 132489-69-1)
Structure
((Z)-PUGNAc, CAS 132489-69-1)
Structure
((Z)-PUGNAc, CAS 132489-69-1)
Related Product Information for C2 Phytoceramide (t18:0/2:0) biochemical
C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 uM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 uM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 uM, and induces internucleosomal DNA fragmentation. In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro.
References
1. Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14(3):837-846.
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Product Notes
The C2 Phytoceramide (t18:0/2:0) (Catalog #AAA227193) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "C2 Phytoceramide (t18:0/2:0), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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