Structure
(Ezeprogind, CAS 615539-20-3)
CDK12-IN-6 biochemical
CDK12-IN-6
Purity
98%
Synonyms
CDK12-IN-6; N/A; AZP-2006; CDK12-IN-6 biochemical
Purity/Purification
98%
CAS
2651196-71-1
Targets&IC50
CDK12:1.19 uM (IC50), CDK2/CyclinE:20 uM (IC50), CDK9/CyclinT1:20 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
CDK12-IN-6 (Example 174) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC 50 =0.872 nM) and has no effect on CAL-120 cells[1]. CDK12-IN-6 has antproliferative activity in MDA-MB-231 cells (IC 50 =2.19 nM) and CAL-120 cells (IC 50 =1 nM)[1]. CDK12-IN-6 has a inhibition IC 50 CDK12 high ATP to Degradation DC 50 CDK12 ratio of 1851[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Ezeprogind, CAS 615539-20-3)
Structure
(Ezeprogind, CAS 615539-20-3)
Structure
(Ezeprogind, CAS 615539-20-3)
Structure
(Ezeprogind, CAS 615539-20-3)
Related Product Information for CDK12-IN-6 biochemical
CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC 50 of 1.19 uM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC 50 20 uM) and CDK9/Cyclin T1 (IC 50 20 uM) at high ATP (2 mM)(WO2021116178A1).
References
1. Alzprotect Strengthens Its Intellectual Property Portfolio for Its First-in-Class Clinical Stage Drug Ezeprogind
2. A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
2. A Study to Assess Tolerability, Safety, Pharmacokinetics and Effect of AZP2006 in Patients With PSP
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Product Notes
The CDK12-IN-6 (Catalog #AAA228568) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CDK12-IN-6, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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