Structure
(HIF-PHD-IN-1, CAS 1567657-46-8)
D,L-erythro-PDMP Biochemical
D,L-erythro-PDMP
Purity
98%
Synonyms
D,L-erythro-PDMP; N/A; D,L-erythro-PDMP biochemical
Purity/Purification
98%
CAS
109760-77-2
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
D,L-erythro-PDMP (0, 12, 25, 50 uM; 0, 4, 7, 10 days) shows an inhibitory effect on cell growth of rabbit skin fibroblasts[1]. D,L-erythro PDMP (50 uM; 3 days) has cytotoxic of rabbit skin fibroblasts on cell morphology[1]. D,L-erythro-PDMP (40 uM; 24 h; MDCK cells) induces a marked increase in glucosyltransferase specific activity: 14.6 nmol/h per mg protein[2]. D,L-erythro-PDMP (40 uM; 6 h) protects the cells against loss of synthase in cells exposed to cycloheximide[2]. Cell Proliferation Assay[1]Cell Line: Rabbit skin fibroblast Concentration: 0, 12, 25, 50 uM Incubation Time: 0, 4, 7, 10 days. Result: Showed an inhibitory effect on cell growth. Cell Cytotoxicity Assay[1]Cell Line: Rabbit skin fibroblast Concentration: 50 uM Incubation Time: 3 days. Result: Had cytotoxic on cell morphology.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(HIF-PHD-IN-1, CAS 1567657-46-8)
Structure
(HIF-PHD-IN-1, CAS 1567657-46-8)
Structure
(HIF-PHD-IN-1, CAS 1567657-46-8)
Structure
(HIF-PHD-IN-1, CAS 1567657-46-8)
Related Product Information for D,L-erythro-PDMP biochemical
D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase.
References
1. Goi T, et, al. Pyrazolo[4,3- d]pyrimidine Derivatives as a Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Inhibitor for the Treatment of Anemia. ACS Med Chem Lett. 2020 Jun 4; 11(7): 1416-1420.
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Product Notes
The D,L-erythro-PDMP (Catalog #AAA227455) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "D,L-erythro-PDMP, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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