Structure
(TLR7/8 agonist 4 TFA, CAS 2388520-34-9)
DL-TBOA ammonium Biochemical | DL-TBOA biochemical
DL-TBOA ammonium
Purity
98%
Synonyms
DL-TBOA ammonium; N/A; DL-TBOA biochemical
Purity/Purification
98%
CAS
2093503-71-8
Targets&IC50
Human EAAT2:5.7 uM (IC50), Human EAAT1:Ki: 42 uM, EAAT4:4.4 uM (IC50), EAAT1:70 uM (IC50), EAAT5:3.2 uM (IC50), EAAT3:6 uM (IC50), EAAT2:6 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
DL-TBOA ammonium (10 nmol; i.c.v.) to morphine-dependent rats significantly facilitates the expression of naloxone-precipitated somatic signs and conditioned place aversion[5]. Animal Model: Male Sprague-Dawley rats (180-250 g)[5]. Dosage: 1 nmol, 3 nmol, 10 nmol. Administration: Intracerebroventricularly injection (i.c.v.). Result: Dose dependently facilitated various somatic signs induced by Naloxone (0.1 mg/kg)-precipitated morphine withdrawal.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(TLR7/8 agonist 4 TFA, CAS 2388520-34-9)
Structure
(TLR7/8 agonist 4 TFA, CAS 2388520-34-9)
Structure
(TLR7/8 agonist 4 TFA, CAS 2388520-34-9)
Structure
(TLR7/8 agonist 4 TFA, CAS 2388520-34-9)
Related Product Information for DL-TBOA biochemical
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC 50 s of 70 uM, 6 uM and 6 uM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ 14 C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with K i valuesof 42 uM and 5.7 uM, respectively. DL-TBOA ammonium blocks EAAT4 and EAAT5 in a competitive manner with K i values of 4.4 uM and 3.2 uM, respectively.
References
1. Shelley Erin ACKERMAN, et al. Macromolecule-supported tlr agonists. WO2020190762A1.
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Product Notes
The DL-TBOA (Catalog #AAA228096) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DL-TBOA ammonium, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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