Structure
(Narceine, CAS 131-28-2)
Donecopride (fumarate hydrate) Biochemical
Donecopride (fumarate hydrate)
Purity
98%
Synonyms
Donecopride (fumarate hydrate); N/A; Narcein; Donecopride (fumarate hydrate) biochemical
Purity/Purification
98%
Solubility
DMSO: 50 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Narceine, CAS 131-28-2)
Structure
(Narceine, CAS 131-28-2)
Structure
(Narceine, CAS 131-28-2)
Structure
(Narceine, CAS 131-28-2)
Related Product Information for Donecopride (fumarate hydrate) biochemical
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (sigma2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-alpha (sAPP-alpha) in COS-7 cells transiently expressing 5-HT4with an EC50value of 11.3 nM. Oral administration of donecopride (1 mg/kg) reduces brain soluble and insoluble amyloid-beta (1-42) levels and increases the time spent exploring the novel object in the novel object recognition (NOR) test in the 5XFAD transgenic mouse model of Alzheimer's disease. Donecopride (3mg/kg, p.o.) prevents a reduction in spontaneous alternation behavior induced by intracerebroventricular administration of soluble Abeta42 (sAbeta42) in the Y-maze in mice.2
References
1. A. Nasir, et al. Characterisation and Anti-diabetic Activity of Phenylquinoline, and Narceine Isolated from Ficus polita Leaf. Annual Research & Review in Biology, Page 102-114.
2. Patricia López, et al. Straightforward analytical method to determine opium alkaloids in poppy seeds and bakery products. Food Chem. 2018 Mar 1;242:443-450.
2. Patricia López, et al. Straightforward analytical method to determine opium alkaloids in poppy seeds and bakery products. Food Chem. 2018 Mar 1;242:443-450.
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Product Notes
The Donecopride (fumarate hydrate) (Catalog #AAA227184) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Donecopride (fumarate hydrate), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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