Structure
(Cecropin P1, porcine, CAS 125667-96-1)
BIO5192 hydrate Biochemical | BIO5192 biochemical
BIO5192 hydrate
Purity
98%
Synonyms
BIO5192 hydrate; N/A; BIO5192 biochemical
Purity/Purification
98%
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis)[2].BIO5192 hydrate (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 hydrate (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h/ng/mL for the 3mg/kg dose to 14,175 h/ng/mL for the 30 mg/kg[1]. Animal Model: C57BL/6J x 129Sv/J F1 mice[1]
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Cecropin P1, porcine, CAS 125667-96-1)
Structure
(Cecropin P1, porcine, CAS 125667-96-1)
Structure
(Cecropin P1, porcine, CAS 125667-96-1)
Structure
(Cecropin P1, porcine, CAS 125667-96-1)
Related Product Information for BIO5192 biochemical
BIO5192 hydrate is a selective and potent integrin alpha4beta1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to alpha4beta1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2].
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Product Notes
The BIO5192 (Catalog #AAA227132) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIO5192 hydrate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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