Structure
(Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH, CAS 908601-15-0)
Doxorubicinol hydrochloride Biochemical
Doxorubicinol hydrochloride
Purity
98%
Synonyms
Doxorubicinol hydrochloride; N/A; Doxorubicinol hydrochloride biochemical
Purity/Purification
98%
CAS
63950-05-0
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
In vivo, in tumor-bearing mice, Nilotinib, acting as ABCB1 inhibitor, is found to increase the accumulation of Doxorubicin and Doxorubicinol hydrochloride in cancer tissues. This implies that weaker anticancer activity of Doxorubicinol hydrochloride may be related to its increased affinity to ABC transporters, thus leading to a lower intracellular concentration of the agent[1]. In comparison with wild-type mice, the terminal half-life and the area under the plasma concentration-time curve of Doxorubicin in mdr1a(-/-) mice are 1.6- and 1.2-fold higher respectively. The retention of both Doxorubicin and its metabolite Doxorubicinol hydrochloride in the hearts of mdr1a(-/-) mice is substantially prolonged[2].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH, CAS 908601-15-0)
Structure
(Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH, CAS 908601-15-0)
Structure
(Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH, CAS 908601-15-0)
Structure
(Fmoc-Trp(Boc)-Ser(psi(Me,Me)pro)-OH, CAS 908601-15-0)
Related Product Information for Doxorubicinol hydrochloride biochemical
Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin.
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Product Notes
The Doxorubicinol hydrochloride (Catalog #AAA228818) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Doxorubicinol hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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