Structure
(N6-Benzyl-5'-ethylcarboxamido adenosine, CAS 152918-32-6)
JAK-2/3-IN-1 biochemical
JAK-2/3-IN-1
Purity
98%
Synonyms
JAK-2/3-IN-1; N/A; JAK-2/3-IN-1 biochemical
Purity/Purification
98%
CAS
1036241-36-7
Targets&IC50
JAK2:<250 nM (Ki), JAK3:<250 nM (Ki)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(N6-Benzyl-5'-ethylcarboxamido adenosine, CAS 152918-32-6)
Structure
(N6-Benzyl-5'-ethylcarboxamido adenosine, CAS 152918-32-6)
Structure
(N6-Benzyl-5'-ethylcarboxamido adenosine, CAS 152918-32-6)
Structure
(N6-Benzyl-5'-ethylcarboxamido adenosine, CAS 152918-32-6)
Related Product Information for JAK-2/3-IN-1 biochemical
JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has K i s of <250 nM for both isoforms.
References
1. C Gallo-Rodriguez, et al. Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists. J Med Chem. 1994 Mar 4;37(5):636-46.
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Product Notes
The JAK-2/3-IN-1 (Catalog #AAA227429) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JAK-2/3-IN-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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