Structure
(SCO-267, CAS 1656261-09-4)
NCT-504 biochemical
NCT-504
Purity
98%
Synonyms
NCT-504; N/A; NCT-504 biochemical
Purity/Purification
98%
CAS
1222765-97-0
Targets&IC50
PIP4Kgamma:15.8 uM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kgamma in the absence of PI5P substrate[1]. NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P[1]. NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC 50 between 50 uM and 100 uM) at 50 uM concentration[1]. NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1]. NCT-504 (10 uM; 12 hours) does not affect cell viability in MEFs[1]. NCT-504 (5 uM, 10 uM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1]. NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1]. NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1]. NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1]. Western Blot Analysis[1]Cell Line: HEK293T cells Concentration: 5 uM, 10 uM Incubation Time: 2 hours, 6 hours. Result: Induced autophagosome formation.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(SCO-267, CAS 1656261-09-4)
Structure
(SCO-267, CAS 1656261-09-4)
Structure
(SCO-267, CAS 1656261-09-4)
Structure
(SCO-267, CAS 1656261-09-4)
Related Product Information for NCT-504 biochemical
NCT-504 is a selective allosteric inhibitor of PIP4Kgamma, with an IC 50 of 15.8 uM. NCT-504 is potential for the research of Huntington's disease.
References
1. Koyama R, et al. Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats. Mol Pharmacol. 2021 Apr;99(4):286-293.
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Product Notes
The NCT-504 (Catalog #AAA227523) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NCT-504, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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