Structure
(Phenylethanolamine A, CAS 1346746-81-3)
NG 25 (hydrochloride hydrate) Biochemical
NG 25 (hydrochloride hydrate)
Purity
98%
Synonyms
NG 25 (hydrochloride hydrate); N/A; NG 25 (hydrochloride hydrate) biochemical
Purity/Purification
98%
Solubility
H2O: 5 mg/mL
<1mg/ml refers to the product slightly soluble or insoluble
<1mg/ml refers to the product slightly soluble or insoluble
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Phenylethanolamine A, CAS 1346746-81-3)
Structure
(Phenylethanolamine A, CAS 1346746-81-3)
Structure
(Phenylethanolamine A, CAS 1346746-81-3)
Structure
(Phenylethanolamine A, CAS 1346746-81-3)
Related Product Information for NG 25 (hydrochloride hydrate) biochemical
NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38alpha (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-alpha-induced IKKalpha/beta phosphorylation and IkappaB-alpha degradation in L929 cells. It inhibits secretion of IFN-alpha and IFN-beta induced by CpG type B and CL097, respectively, in Gen2.2 cells in a concentration-dependent manner.2NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration-dependent manner.3It also reduces tumor growth and increases the number of TUNEL-positive tumor cells in a CT26KRASG12Dmouse orthotopic model of colorectal cancer.
References
1. Mingxin Li, et al. Ultrasensitive and Quantitative Detection of a New beta-agonist Phenylethanolamine A by a Novel Immunochromatographic Assay Based on Surface-Enhanced Raman Scattering (SERS). J Agric Food Chem. 2014 Nov 12;62(45):10896-902.
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Product Notes
The NG 25 (hydrochloride hydrate) (Catalog #AAA227209) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NG 25 (hydrochloride hydrate), Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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