Structure
(Ni(II) protoporphyrin IX, CAS 15415-30-2)
PF-03622905 biochemical
PF-03622905
Purity
98%
Synonyms
PF-03622905; N/A; PF-03622905 biochemical
Purity/Purification
98%
CAS
1072100-15-2
Targets&IC50
PKCalpha:5.6 nM (IC50), PKCtheta:74.1 nM (IC50), PKCgamma:37.7 nM (IC50), PKCbetaI:14.5 nM (IC50), PKCbetaII:13 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
PF-03622905 causes concentration-dependent inhibition of phospho-ERK1/2 formation, interleukin 8 release, and phospho-SHP2 levels with an IC 50 value 0.15 uM, 0.16 uM, and 35 nM, respectively[1]. PF-03622905 shows low cytotoxicity at 1 uM against human umbilical vein endothelial cells with remaining cell viability at 83.3% viable[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Ni(II) protoporphyrin IX, CAS 15415-30-2)
Structure
(Ni(II) protoporphyrin IX, CAS 15415-30-2)
Structure
(Ni(II) protoporphyrin IX, CAS 15415-30-2)
Structure
(Ni(II) protoporphyrin IX, CAS 15415-30-2)
Related Product Information for PF-03622905 biochemical
PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC 50 s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, and PKCtheta, respectively. PF-03622905 shows high specificity for PKC over other protein kinases.
References
1. Lu Y, et al. Binding of protoporphyrin IX and metal derivatives to the active site of wild-type mouse ferrochelatase at low porphyrin-to-protein ratios. Biochemistry. 2002;41(26):8253-8262.
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Product Notes
The PF-03622905 (Catalog #AAA227443) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-03622905, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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