Structure
PF-04136309 Biochemical
PF-04136309
Purity
>98% (HPLC)
Synonyms
PF-04136309; N/A; INCB8761; PF-4136309; PF4136309; PF-04136309 biochemical
Purity/Purification
>98% (HPLC)
Solubility
DMSO: >32mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Chemokine Receptor
Receptor
CCR2
Pathway
GPCR/G Protein
Chemical Name
(S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
SMILES
O=C(NCC(N1C[C@@H](NC2CCC(C3=NC=C(C4=NC=CC=N4)C=C3)(O)CC2)CC1)=O)C5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C29H31F3N6O3
CAS Number
1341224-83-6
Preparation and Storage
Store at -20°C.
Structure
Structure
Related Product Information for PF-04136309 biochemical
PF-4136309 (INCB8761) is a potent, selective, competitive, reversible full CCR2 antagonist with IC50 of 2-5nM; depletes inflammatory monocytes and macrophages from the primary tumor and premetastatic liver resulting in enhanced antitumor immunity, decreased tumor growth, and reduced metastasis. Pancreatic Cancer Phase 2 Clinical
Product Categories/Family for PF-04136309 biochemical
References
1. Sanford DE, et al. Clin Cancer Res. 2013 Jul 1; 19 (13):3404-15.
2. Nywening TM, et al. Lancet Oncol. 2016 May; 17 (5):651-62.
3.Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5; 2 (12):913-8.
2. Nywening TM, et al. Lancet Oncol. 2016 May; 17 (5):651-62.
3.Xue CB, et al. ACS Med Chem Lett. 2011 Oct 5; 2 (12):913-8.
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Product Notes
The PF-04136309 (Catalog #AAA201900) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-04136309, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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