Structure
(Indicine N-oxide, CAS 41708-76-3)
Pomalidomide-PEG3-C2-NH2 hydrochloride Biochemical
Pomalidomide-PEG3-C2-NH2 hydrochloride
Purity
98%
Synonyms
Pomalidomide-PEG3-C2-NH2 hydrochloride; N/A; NSC132319; (+)-Indicine N-oxide; Pomalidomide-PEG3-C2-NH2 hydrochloride biochemical
Purity/Purification
98%
CAS
2446474-09-3
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Indicine N-oxide, CAS 41708-76-3)
Structure
(Indicine N-oxide, CAS 41708-76-3)
Structure
(Indicine N-oxide, CAS 41708-76-3)
Structure
(Indicine N-oxide, CAS 41708-76-3)
Related Product Information for Pomalidomide-PEG3-C2-NH2 hydrochloride biochemical
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
References
1. V M Whitehead, et al. Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1990;26(5):377-9.
2. J S Kovach, et al. Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans. Cancer Res. 1979 Nov;39(11):4540-4.
2. J S Kovach, et al. Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans. Cancer Res. 1979 Nov;39(11):4540-4.
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Product Notes
The Pomalidomide-PEG3-C2-NH2 hydrochloride (Catalog #AAA228444) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pomalidomide-PEG3-C2-NH2 hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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