Structure
(Biotin-C4-amide-C5-NH2, CAS 151294-96-1)
(R)-Fadrozole Biochemical
(R)-Fadrozole
Purity
98%
Synonyms
(R)-Fadrozole; N/A; (R)-Fadrozole biochemical
Purity/Purification
98%
CAS
102676-87-9
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
(R)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2]. (R)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2]. Animal Model: SHHF rats[2]. Dosage: 0.24 and 1.2 mg/kg. Administration: Daily; oral. Result: Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Biotin-C4-amide-C5-NH2, CAS 151294-96-1)
Structure
(Biotin-C4-amide-C5-NH2, CAS 151294-96-1)
Structure
(Biotin-C4-amide-C5-NH2, CAS 151294-96-1)
Structure
(Biotin-C4-amide-C5-NH2, CAS 151294-96-1)
Related Product Information for (R)-Fadrozole biochemical
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.
References
1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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Product Notes
The (R)-Fadrozole (Catalog #AAA227423) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "(R)-Fadrozole, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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