Structure
(Chlorin e6 trimethyl ester, CAS 35038-32-5)
RB-3 biochemical
RB-3
Purity
98%
Synonyms
RB-3; N/A; RB-3 biochemical
Purity/Purification
98%
CAS
2396639-11-3
Targets&IC50
RING1B-BMI1f:2.8 uM (Kd)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
RB-3 decreases the global level of H2A ubiquitination and induces differentiation in leukemia cell lines and primary acute myeloid leukemia (AML) samples[1]. RB-3 inhibits H2A ubiquitination with an IC 50 of 1.6 uM[1]. RB-3 inhibits PRC1 and disrupts the interaction with nucleosomes[1]. RB-3 reduces colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model[1]. Western Blot Analysis[1]Cell Line: TEX cells. Concentration: 6, 12, 25 uM. Incubation Time: 8d. Result: Dose-dependently increased C/EBPalpha-p42 protein levels.
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Chlorin e6 trimethyl ester, CAS 35038-32-5)
Structure
(Chlorin e6 trimethyl ester, CAS 35038-32-5)
Structure
(Chlorin e6 trimethyl ester, CAS 35038-32-5)
Structure
(Chlorin e6 trimethyl ester, CAS 35038-32-5)
Related Product Information for RB-3 biochemical
RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a K d of 2.8 uM.
References
1. Pandey RK, et, al. Chlorin and porphyrin derivatives as potential photosensitizers in photodynamic therapy. Photochemistry and Photobiology. 1991. 53(1):65-72.
2. Bauer D, et, al. Functionalization of chlorin e6 trimethylester towards potential amphiphilic photosensitizers for photodynamic therapy. Journal of Porphyrins and Phthalocyanines. 2019. 23(3): 243-250.
2. Bauer D, et, al. Functionalization of chlorin e6 trimethylester towards potential amphiphilic photosensitizers for photodynamic therapy. Journal of Porphyrins and Phthalocyanines. 2019. 23(3): 243-250.
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Product Notes
The RB-3 (Catalog #AAA228394) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RB-3, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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