Structure
(Bis-PEG6-t-butyl ester, CAS 439114-12-2)
SGC-CK2-1 biochemical
SGC-CK2-1
Purity
98%
Synonyms
SGC-CK2-1; N/A; SGC-CK2-1 biochemical
Purity/Purification
98%
CAS
2470424-39-4
Targets&IC50
CK2alpha:36 nM (IC50), CK2alpha':16 nM (IC50)
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
In vitro
SGC-CK2-1 inhibits CSNK2A2 and CSNK2A1 with IC50 values of 2.3 and 4.2 nM[1]. SGC-CK2-1 inhibits DYRK2 with the IC 50 value of 3.7 uM[1]. SGC-CK2-1 inhibits blood U-937, MV4-11, MOLM-13, OCI-LY19, OCI-AML5 cells with IC50s of 120, 690, 750, 760 and 810 nM, respectively. SGC-CK2-1 inhibits Head/Neck Detroit562 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Lung NCI-H2286 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Brain SK-N-MC cells with an IC 50 of 730 nM. SGC-CK2-1 inhibits Breast BT-20 cells with an IC 50 of 810 nM. SGC-CK2-1 inhibits Skin A375 cells with an IC 50 of 830 nM. SGC-CK2-1 inhibits Stomach SNU-1 cells with an IC 50 of 860 nM. SGC-CK2-1 inhibits DuodenuM/hutu 80 cells with an IC 50 of 920 nM[1].
Preparation and Storage
Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years
In solvent: -80 degree C for 2 years
Structure
(Bis-PEG6-t-butyl ester, CAS 439114-12-2)
Structure
(Bis-PEG6-t-butyl ester, CAS 439114-12-2)
Structure
(Bis-PEG6-t-butyl ester, CAS 439114-12-2)
Structure
(Bis-PEG6-t-butyl ester, CAS 439114-12-2)
Related Product Information for SGC-CK2-1 biochemical
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2alpha and CK2alpha?respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases.
References
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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Product Notes
The SGC-CK2-1 (Catalog #AAA228460) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SGC-CK2-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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