SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
BIRC7 recombinant protein
BIRC7, Active
Gene Names
BIRC7; KIAP; LIVIN; MLIAP; RNF50; ML-IAP
Applications
Western Blot
Synonyms
BIRC7; N/A; BIRC7, Active; KIAP; LIVIN; ML-IAP; MLIAP; RNF50; BIRC7 recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant proteins stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for BIRC7 recombinant protein
WB (Western Blot)
Tag
GST
Species
Human
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-PAGE
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Activity Plot. For specific information on a given lot, see related technical data sheet.)
Related Product Information for BIRC7 recombinant protein
Recombinant full-length human BIRC7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The BIRC7 gene accession number is BC014475.
Baculoviral IAP repeat-containing protein 7 (BIRC7) is a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family whose activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase. Highly expressed in tumor tissues and inhibits tumor cell apoptosis through blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. BIRC7 expression in breast cancer correlated with the clinical stage and axillary lympHnode metastasis, and promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells.
Baculoviral IAP repeat-containing protein 7 (BIRC7) is a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family whose activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase. Highly expressed in tumor tissues and inhibits tumor cell apoptosis through blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. BIRC7 expression in breast cancer correlated with the clinical stage and axillary lympHnode metastasis, and promotes breast cancer metastasis through the activation of AKT signaling and induction of EMT in breast cancer cells.
Product Categories/Family for BIRC7 recombinant protein
References
1. Ma, L. et al: Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. Cell Death Differ. 13:2079-2088, 2006
2. Li, F. et al: Livin promotes progression of breast cancer through induction of epithelial-mesenchymal transition and activation of AKT signaling. Cell Signal. 25(6):1413-1422, 2013
2. Li, F. et al: Livin promotes progression of breast cancer through induction of epithelial-mesenchymal transition and activation of AKT signaling. Cell Signal. 25(6):1413-1422, 2013
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
30,866 Da
NCBI Official Full Name
Homo sapiens baculoviral IAP repeat-containing 7, mRNA
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 7
NCBI Official Symbol
BIRC7
NCBI Official Synonym Symbols
KIAP; LIVIN; MLIAP; RNF50; ML-IAP
NCBI Protein Information
baculoviral IAP repeat-containing protein 7
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Product Notes
The BIRC7 (Catalog #AAA73283) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's BIRC7 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the BIRC7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BIRC7, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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