BLVRB blocking peptide
BLVRB Blocking Peptide (C-term)
Gene Names
BLVRB; FLR; BVRB; SDR43U1; HEL-S-10
Synonyms
BLVRB; N/A; BLVRB Blocking Peptide (C-term); Flavin reductase (NADPH); FR; Biliverdin reductase B; BVR-B; Biliverdin-IX beta-reductase; Green heme-binding protein; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; FLR; BLVRB blocking peptide
Specificity
The synthetic peptide sequence is selected from aa 161-195 of HUMAN BLVRB
Form/Format
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Sequence Length
206
Cellular Location
Cytoplasm.
Tissue Location
Predominantly expressed in liver and erythrocytes (PubMed:7929092). At lower levels in heart, lung, adrenal gland and cerebrum (PubMed:7929092). Expressed in adult red blood cells (PubMed:29932944).
Function
Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent
nitrosyltransferase (PubMed: , PubMed: , PubMed: , PubMed: , PubMed: ). Promotes fetal heme degradation during development
(PubMed: ,
PubMed: ,
PubMed: ).
Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary
metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed: , PubMed: , PubMed: ). Has a broad specificity oxidoreductase activity by catalyzing
the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN,
biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (PubMed:10620517, PubMed:18241201, PubMed:7929092). Contributes to
fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver
(PubMed: ,
PubMed: ,
PubMed: ).
Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult
(PubMed: ,
PubMed: ,
PubMed: ).
Does not reduce bilirubin IXalpha (PubMed: , PubMed: , PubMed: ). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the
presence of FMN and NADPH (PubMed: ). Acts as a protein nitrosyltransferase by catalyzing nitrosylation
of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-
nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism:
BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then
transferred from S- nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-
nitroso-BLVRB to the protein substrate (PubMed:38056462). Inhibits
insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition
(PubMed: ).
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for BLVRB blocking peptide
Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Flavin reductase (NADPH)
NCBI Official Synonym Full Names
biliverdin reductase B
NCBI Official Symbol
BLVRB
NCBI Official Synonym Symbols
FLR; BVRB; SDR43U1; HEL-S-10
NCBI Protein Information
flavin reductase (NADPH)
UniProt Protein Name
Flavin reductase (NADPH)
UniProt Gene Name
BLVRB
UniProt Synonym Gene Names
FLR; BVR-B; GHBP; FLR
UniProt Entry Name
BLVRB_HUMAN
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Product Notes
The BLVRB blvrb (Catalog #AAA290823) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BLVRB, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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