SCNN1A blocking peptide
SCNN1A Antibody (Center) Blocking Peptide
Gene Names
SCNN1A; BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha
Synonyms
SCNN1A; N/A; SCNN1A Antibody (Center) Blocking Peptide; Amiloride-sensitive sodium channel subunit alpha; Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN1; SCNN1A blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human SCNN1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
669
Cellular Location
Apical cell membrane; Multi-pass membrane protein. Cell projection, cilium. Note: In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces
Tissue Location
Expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium (at protein level). Expressed in kidney (at protein level). In the respiratory tract, expressed in the bronchial epithelium (at protein level). Highly expressed in lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for SCNN1A blocking peptide
Nonvoltage-gated, amiloride-sensitive, sodiumchannels control fluid and electrolyte transportacross epithelia in many organs. These channelsare heteromeric complexes consisting of 3subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in thisgene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a raresalt wasting disease resulting from target organun responsiveness to mineralocorticoids.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Amiloride-sensitive sodium channel subunit alpha
NCBI Official Synonym Full Names
sodium channel epithelial 1 alpha subunit
NCBI Official Symbol
SCNN1A
NCBI Official Synonym Symbols
BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha
NCBI Protein Information
amiloride-sensitive sodium channel subunit alpha
UniProt Protein Name
Amiloride-sensitive sodium channel subunit alpha
UniProt Gene Name
SCNN1A
UniProt Synonym Gene Names
SCNN1; Alpha-ENaC; ENaCA
UniProt Entry Name
SCNNA_HUMAN
Similar Products
Product Notes
The SCNN1A scnn1a (Catalog #AAA290817) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SCNN1A, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.