SDS-PAGE
CaSR recombinant protein
Recombinant Human CaSR protein (His tag)
Gene Names
CASR; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A
Purity
>95 % as determined by reducing SDS-PAGE.
Synonyms
CaSR; N/A; Recombinant Human CaSR protein (His tag); Ca sensing receptor; Ca2+ sensing receptor 1; CAR; EIG8; Extracellular calcium sensing receptor; FHH; FIH; GPRC2A; HHC1; NSHPT; PCAR 1; PCaR1; CaSR recombinant protein
Host
E Coli
Purity/Purification
>95 % as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4.
Sequence
Lys 863-Ser 1078
Species
Human
Tag
N-His
Reconstitution
MBS recommends centrifuging the vial before opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water be added to the vial to prepare a stock solution of 1 mg/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Generally, lyophilized proteins are stable for up to 12 months when stored at -20°C to -80°C. Reconstituted protein solution can be stored at 4°C to 8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
SDS-PAGE
SDS-PAGE
Related Product Information for CaSR recombinant protein
CaSR, the extracellular Calcium-Sensing Receptor, is a widely expressed G-protein coupled receptor (GPCR) involved in calcium homeostasis. CaSR operates as a sensor in parathyroid and kidney, and alterations in its activity have been shown to cause thyroid disease in humans. Activation of the receptor in response to extracellular calcium or other ligands causes activation of phospholipase C (PLC), release of IP3 and release of calcium from intracellular stores. Proinflammatory cytokines IL-1beta and TNF-alpha increase CaSR gene expression in human thyroid and kidney cells through activation of the NF-kappaB pathway, and this pathway may be involved in hypocalcemia often seen in critically ill patients. Elevated calcium concentration and CaSR expression have been linked to proliferation and metastasis of skeletal metastatic prostate cancer cell lines. In intestinal epithelial cells, CaSR is involved in regulation of cyclic nucleotide metabolism and the fluid secretion that results in life-threatening fluid loss in response to intestinal pathogens. The interaction of CaSR with the actin-binding protein filamin may provide scaffolding for the organization of signaling pathways converging on the cytoskeleton, including CaSR-mediated MAPK pathway activation.
Product Categories/Family for CaSR recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 23.65 kDa
Aproximate Molecular Mass: 35kDa
Aproximate Molecular Mass: 35kDa
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 2
NCBI Official Synonym Full Names
calcium-sensing receptor
NCBI Official Symbol
CASR
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A
NCBI Protein Information
extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Gene Name
CASR
UniProt Synonym Gene Names
GPRC2A; PCAR1; CaSR; PCaR1
UniProt Entry Name
CASR_HUMAN
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Product Notes
The CaSR casr (Catalog #AAA178166) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Lys 863-Ser 1078. It is sometimes possible for the material contained within the vial of "CaSR, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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