SDS-PAGE
(SDS PAGE for Recombinant Human BP180/NC16a Protein)
BP180/NC16a recombinant protein
Recombinant Human BP180/NC16a Protein
Gene Names
COL17A1; BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
Purity
>95% as determined by SDS-PAGE
Synonyms
BP180/NC16a; N/A; Recombinant Human BP180/NC16a Protein; Linear IgA disease antigen 1; COL17A1; 180 kDa bullous pemphigoid antigen 2; LAD-1; Linear IgA bullous disease antigen of 97 kDa; 120 kDa linear IgA dermatosis antigen; 97-LAD; Collagen alpha-1(XVII) chain; Bullous pemphigoid antigen 2; 97 kDa linear IgA bullous dermatosis antigen; LABD97; 97 kDa LAD antigen; BPAG2; BP180; BP180/NC16a recombinant protein
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Lyophilized from PBS pH7.4,0.02%NLS,1mM EDTA, 4%trehalose,1% mannitol.
Species
Human
Reconstitution
Reconstitute in sterile water for a stock solution.
Protein Length
Confidential
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
SDS-PAGE
(SDS PAGE for Recombinant Human BP180/NC16a Protein)
SDS-PAGE
(SDS PAGE for Recombinant Human BP180/NC16a Protein)
Related Product Information for BP180/NC16a recombinant protein
Bullous pemphigoid is the result of an attack on the basement membrane of the epidermis by IgG +/- IgE immunoglobulins (antibodies) and activated T lymphocytes (white blood cells). The target is the protein BP180 (also called Type XVII collagen), or less frequently BP230 (a plakin). These proteins are within the NC16A domain of collagen XVII. They are associated with the hemidesmosomes, structures that ensure the epidermal keratinocyte cells stick to the dermis to make a waterproof seal. The binding of the autoantibodies to the proteins and release of cytokines from the T cells lead to complement activation, recruitment of neutrophils (acute inflammatory cells) and the release of proteolytic enzymes. These destroy the hemidesmosomes and cause the formation of subepidermal blisters.
Product Categories/Family for BP180/NC16a recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
collagen alpha-1(XVII) chain
NCBI Official Synonym Full Names
collagen, type XVII, alpha 1
NCBI Official Symbol
COL17A1
NCBI Official Synonym Symbols
BP180; BPA-2; BPAG2; LAD-1; BA16H23.2
NCBI Protein Information
collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type X
UniProt Protein Name
Collagen alpha-1(XVII) chain
UniProt Gene Name
COL17A1
UniProt Synonym Gene Names
BP180; BPAG2; LAD-1; 97 kDa LAD antigen; 97-LAD; LABD97
UniProt Entry Name
COHA1_HUMAN
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Product Notes
The BP180/NC16a col17a1 (Catalog #AAA120534) is a Recombinant Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BP180/NC16a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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