Application Data
COMT recombinant protein
COMT, Active
Gene Names
COMT; HEL-S-98n
Applications
Methyltransferase Assay
Synonyms
COMT; N/A; COMT, Active; COMT recombinant protein
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Sequence Positions
27-271
Sequence Length
2304
Applicable Applications for COMT recombinant protein
Methyltransferase Assay
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for COMT recombinant protein
Description: Recombinant human COMT (27-271) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: Catechol O-methyltransferase (COMT) is a major catabolic regulator of synaptic catecholamine neurotransmitters and it catalyzes the transfer of a methyl group to catecholamines and degrades dopamine, norepinephrine and epinephrine. The two forms of COMT (soluble COMT [S-COMT] and membrane-bound COMT [MB-COMT]) encoded by a single gene located on 22q11.2 have been identified. Activation of COMT affects the biological half-lives of certain neuroactive drugs.
Scientific Background: Catechol O-methyltransferase (COMT) is a major catabolic regulator of synaptic catecholamine neurotransmitters and it catalyzes the transfer of a methyl group to catecholamines and degrades dopamine, norepinephrine and epinephrine. The two forms of COMT (soluble COMT [S-COMT] and membrane-bound COMT [MB-COMT]) encoded by a single gene located on 22q11.2 have been identified. Activation of COMT affects the biological half-lives of certain neuroactive drugs.
Product Categories/Family for COMT recombinant protein
References
1. Pivac N, et al: The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Genes Brain Behav. 2011;10 (5):565 -9 2. Wardle MC, et al: Does COMT genotype influence the effects of d-amphetamine on executive functioning Genes Brain Behav. 2013;12 (1):13 -20. 3.http://www.uniprot.org/uniprot/P21964
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53 kDa
NCBI Official Full Name
Homo sapiens catechol-O-methyltransferase (COMT), transcript variant 1, mRNA
NCBI Official Synonym Full Names
catechol-O-methyltransferase
NCBI Official Symbol
COMT
NCBI Official Synonym Symbols
HEL-S-98n
NCBI Protein Information
catechol O-methyltransferase
UniProt Protein Name
Catechol O-methyltransferase
UniProt Gene Name
COMT
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Product Notes
The COMT comt (Catalog #AAA72975) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-271. AAA Biotech's COMT can be used in a range of immunoassay formats including, but not limited to, Methyltransferase Assay. Researchers should empirically determine the suitability of the COMT comt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COMT, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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