Application Data
DPP3 recombinant protein
Recombinant Human DPP3 Protein (His Tag), HPLC-verified
Gene Names
DPP3; DPPIII
Reactivity
Human
Purity
>= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Synonyms
DPP3; N/A; Recombinant Human DPP3 Protein (His Tag), HPLC-verified; Human DPP3 Protein (His Tag); dipeptidyl-peptidase 3; DPPIII Protein, Human; DPP3 recombinant protein
Host
E coli
Reactivity
Human
Purity/Purification
>= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
Form/Format
Supplied as sterile 50mM Tris, 150mM NaCl, 10% Glycerol, 0.02% (w/v) Brij-35, pH 9.0.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hardcopy of datasheet.
Sequence
Ala2-Ala737
Tag
N-His
Predicted N Terminal
Met
Endotoxin
< 1.0 EU perug of the protein as determined by the LAL method
Protein Construction
A DNA sequence encoding the Human DPP3 (Q9NY33)(Ala2-Ala737) was expressed, with a polyhistidine tag at the N-terminus.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Liquid. It is shipped out with blue ice.
Liquid. It is shipped out with blue ice.
Application Data
Application Data
Application Data
Application Data
Related Product Information for DPP3 recombinant protein
Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent peptidase distributed within the cytoplasm which cleaves dipeptides sequentially from the N-terminus of bioactive peptide substrates 4+ amino acid residues in length. DPP3 adopts a bi-lobed structure and features HEXXGH and EEXRAE/D motifs which coordinate the Zn2+ion in its active site. DPP3's gene is located on chromosome 11q12-13.113. DPP3 regulates the transformation of enkephalin, opioid peptide, terminal protein, and cell signaling. Deficiency results in ROS formation in the kidneys via elevated Angiotensin II (DPP3's most prominent reported substrate), III, IV, and ANG (1-5). DPP3 is linked to the development of cardiovascular diseases through RAS, oxidative stress, and inflammation pathways. Depletion was associated with the upregulation of proapoptotic proteins SMAC and p53, making it a potential target in tumor therapy.
References
1. Y. P. e. al. DPP3. Fro. biomarke. t. therapeuti. targe. o. cardiovascula. diseases. Fron. Cardiovas. Med. 2022. doi. 10.3389/fcvm.2022.97403. 2. Malovan. G.. e. al.. Th. emergin. rol. o. dipeptidy. peptidas. . i. pathophysiology. FEB. J. 2023. doi. 10.1111/febs.1642. 3. Tong. Y.. e. al. DPP3/CDK. contribute. t. th. progressio. o. colorecta. cance. throug. regulatin. cel. proliferation. cel. apoptosis. an. cel. migration. Cel. Deat. Dis. 2021. doi. 10.1038/s41419-021-03796-. 4. Liu. J.. e. al. DPP. expressio. promote. cel. proliferatio. an. migratio. invitr. an. tumou. growt. invivo. whic. i. associate. wit. poo. prognosi. o. oesophagea. carcinoma. Oncolog. Reports. 2023. doi. 10.3892/or.2022.8446
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
69,658 Da
NCBI Official Full Name
dipeptidyl peptidase 3 isoform 2
NCBI Official Synonym Full Names
dipeptidyl-peptidase 3
NCBI Official Symbol
DPP3
NCBI Official Synonym Symbols
DPPIII
NCBI Protein Information
dipeptidyl peptidase 3; DPP III; dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase III; enkephalinase B
UniProt Protein Name
Dipeptidyl peptidase 3
UniProt Gene Name
DPP3
UniProt Synonym Gene Names
DPP III
UniProt Entry Name
DPP3_HUMAN
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Product Notes
The DPP3 dpp3 (Catalog #AAA259287) is a Recombinant Protein produced from E coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Human DPP3 Protein (His Tag), HPLC-verified reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Ala2-Ala73 7. It is sometimes possible for the material contained within the vial of "DPP3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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