GDF11 active protein
GDF11 protein
Gene Names
GDF11; BMP11; BMP-11
Applications
User optimized.
Purity
> 98% by SDS-PAGE analysis and HPLC
Synonyms
GDF11; N/A; GDF11 protein; BMP-11 protein; GDF 11 protein; GDF-11 protein; GDF-11; Growth/Differentiation Factor-11 protein; GDF 11; GDF11 active protein
Host
E. coli
Purity/Purification
> 98% by SDS-PAGE analysis and HPLC
Form/Format
Sterile Filtered through a 0.2 micron filter. Lyophilized with no additives. Centrifuge vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0mg/ml. Keep pH below 5.0. Do not vortex.
Concentration
20 ug per vial: lyophilized (varies by lot)
Sequence
Region of GDF11 protein corresponding to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS.
Applicable Applications for GDF11 active protein
User optimized.
Grade
Recombinant
Species
Human
Contaminants
Endotoxin level is <0.1ng/ug
Biological Activity
The biological activity is determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 cells. The ED50 for this effect is 8 to 10 ng/ml.
Biohazard
Use normal laboratory precautions and techniques when handling this reagent.
Preparation and Storage
Ships ambient or refrigerated. Upon receipt store at -20°C. After reconstituted, the undiluted solution is stable at 4°C for up to 1 week. For extended storage, dilute further in a buffer containing a carrier protein (0.1% BSA) and store in working aliquots at -20°C to -80°C. Avoid repeat freeze-thaw cycles.
Related Product Information for GDF11 active protein
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same.
Product Categories/Family for GDF11 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25kDa
NCBI Official Full Name
growth/differentiation factor 11
NCBI Official Synonym Full Names
growth differentiation factor 11
NCBI Official Symbol
GDF11
NCBI Official Synonym Symbols
BMP11; BMP-11
NCBI Protein Information
growth/differentiation factor 11
UniProt Protein Name
Growth/differentiation factor 11
UniProt Gene Name
GDF11
UniProt Synonym Gene Names
BMP11; GDF-11; BMP-11
UniProt Entry Name
GDF11_HUMAN
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Product Notes
The GDF11 gdf11 (Catalog #AAA14381) is an Active Protein produced from E. coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GDF11 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the GDF11 gdf11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of GDF11 protein correspond ing to amino acids NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS. It is sometimes possible for the material contained within the vial of "GDF11, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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