IL21 active protein
IL21 protein
Gene Names
IL21; Za11; IL-21; CVID11
Purity
> 95.0% by SDS-PAGE
Synonyms
IL21; N/A; IL21 protein; Za11 protein; Interleukin 21 protein; IL 21; IL-21; IL 21 protein; IL-21 protein; IL21 active protein
Host
E.coli
Purity/Purification
> 95.0% by SDS-PAGE
Form/Format
Lyophilized powder from PBS, pH7.4. Reconstitute in sterile 18 Momega-cm H2O to not less than 100ug/ml which can then be diluted further with aqueous solutions.
Concentration
10ug, lyophilized (varies by lot)
Sequence Length
162
Protein Type
Recombinant
Biological Significance
IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (
Bioactivity
ED50 = 1.0-10 ng/ml, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells.
Biohazard
Use appropriate laboratory precautions when handling this product.
Preparation and Storage
Ships ambient or refrigerated. After receipt, store at 4 degree C for short term, -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for IL21 active protein
Purified recombinant Human IL21 protein
Product Categories/Family for IL21 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,463 Da
NCBI Official Full Name
interleukin-21 isoform 1
NCBI Official Synonym Full Names
interleukin 21
NCBI Official Symbol
IL21
NCBI Official Synonym Symbols
Za11; IL-21; CVID11
NCBI Protein Information
interleukin-21
UniProt Protein Name
Interleukin-21
UniProt Gene Name
IL21
UniProt Synonym Gene Names
IL-21
UniProt Entry Name
IL21_HUMAN
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Product Notes
The IL21 il21 (Catalog #AAA75599) is an Active Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IL21, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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