Galectin-3 Active Protein | LGALS3 active protein
Human Galectin-3
Gene Names
LGALS3; L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
Galectin-3; N/A; Human Galectin-3; Recombinant Human Galectin-3; LGALS3 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized from 0.5x PBS, pH 7.2
Sequence
ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPG QAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS S GQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTV KPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GR EERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLN EI SKLGISGDID LTSASYTMI
Sequence Length
250
Endotoxin Level
< 0.1 ng per ug of Galectin-3
Biological Activity
Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 ug/ml with a peak response obtained at 250 ug/ml.
Reconstitution
The human Galectin-3 should be reconstituted in water to a concentration of 0.1-1.0 mg/ml. Do not vortex! This solution can be diluted in water or other buffer solutions or stored at -20 degree C.
Preparation and Storage
The lyophilized protein is stable for a 1 month at room temperature or 6 months at 4 degree C. The reconstituted protein is stable for 1 week at 2 degree C to 8 degree C and 3 months at -20 degreeC to 8 degree c and 3 months at -20 degree C to -80 degree C. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (e.g. 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Related Product Information for LGALS3 active protein
Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0 kDa protein containing 250 amino acid residues, but no disulfide bonds.
Product Categories/Family for LGALS3 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
26.0 kDa
NCBI Official Full Name
galectin-3 isoform 1
NCBI Official Synonym Full Names
lectin, galactoside-binding, soluble, 3
NCBI Official Symbol
LGALS3
NCBI Official Synonym Symbols
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
NCBI Protein Information
galectin-3; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35
UniProt Protein Name
Galectin-3
UniProt Gene Name
LGALS3
UniProt Synonym Gene Names
MAC2; Gal-3; CBP 35; GALBP
UniProt Entry Name
LEG3_HUMAN
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Product Notes
The LGALS3 lgals3 (Catalog #AAA79140) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Galectin-3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPG QAPP GAYPGQAPPG AYHGAPGAYP GAPAPGVYPG PPSGPGAYPS S GQPSAPGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTV KPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GR EERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLN EI SKLGISGDID LTSASYTMI. It is sometimes possible for the material contained within the vial of "Galectin-3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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