Application Data
IL-1 beta active protein
Human IL-1 beta
Gene Names
IL1B; IL-1; IL1F2; IL1-BETA
Reactivity
Human
Purity
> 98% by SDS-PAGE & silver stain
Synonyms
IL-1 beta; N/A; Human IL-1 beta; Recombinant Human Interleukin-1 beta; Catabolin; IL1F2; IL-1 beta active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE & silver stain
Form/Format
Lyophilized
Sequence
N-Terminal Sequence: APVRSL and MAPVRS
Sequence Length
153
Endotoxin Level
< 0.1ng per ug (IEU/ug) of rh IL-1 beta
Buffer
PBS
Preparation and Storage
Lyophilized IL-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL-1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for IL-1 beta active protein
Interleukin-1 beta (IL-1beta) is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1beta proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL1F1) and IL1 beta (IL1F2), which are the products of distinct genes. IL- 1alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta converting enzyme (Caspase1/ICE) to generate the active cytokine. The mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67% 78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta. Human recombinant IL-1beta produced in E. coli is a non-glycosylated, IL-1 beta polypeptide chain containing 153 amino acids and having a molecular mass of 17.0 kDa.
Product Categories/Family for IL-1 beta active protein
References
1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629. 2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229. 3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S. 4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21. 5. March, C.J. et al. (1985) Nature 315:641. 6. Auron, P.E. et al. (1984) Proc. Natl. Acad. Sci. 81:7907. 7. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17.0Da
NCBI Official Full Name
interleukin-1 beta proprotein
NCBI Official Synonym Full Names
interleukin 1, beta
NCBI Official Symbol
IL1B
NCBI Official Synonym Symbols
IL-1; IL1F2; IL1-BETA
NCBI Protein Information
interleukin-1 beta; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta
UniProt Protein Name
Interleukin-1 beta
UniProt Gene Name
IL1B
UniProt Synonym Gene Names
IL1F2; IL-1 beta
UniProt Entry Name
IL1B_HUMAN
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Product Notes
The IL-1 beta il1b (Catalog #AAA79233) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-1 beta reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: N-Terminal Sequence: APVRSL and MAPVRS. It is sometimes possible for the material contained within the vial of "IL-1 beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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