Soluble RANK Ligand Active Protein | sRANKL active protein

Recombinant Human Soluble RANK Ligand

Cat. Num. AAA38163

• Gene Names: TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
• Purity: Greater than 90.0% as determined by analysis by SDS-PAGE.
• Synonyms: Soluble RANK Ligand; N/A; Recombinant Human Soluble RANK Ligand; sRANKL Human; RANK Ligand Soluble Human Recombinant; Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE; TNF-related activation-induced cytokine; OPGL; ODF; Osteoclast differentiation factor; Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa B ligand; RANKL; Osteoprotegerin ligand; CD254 antigen; sRANKL; sOdf; hRANKL2; sRANKL active protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by analysis by SDS-PAGE.
• Form/Format: The protein was lyophilized from a concentrated (1mg/ml) solution containing 10mM Sodium phosphate, pH 7.5
• Sequence: EKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID
• Sequence Length: 317

• Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized sRANKL in sterile 18M Omega -cm H2O at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The activity of RAW-BLUE was measured to be 40.4 ng/mL, corresponding to a specific activity of 2.5 x 10 ⁴ units/mg.
• Preparation and Storage: Lyophilized sRANKL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sRANKL should be stored at 4 degree C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for sRANKL active protein

Description: sRANKL Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids and having a molecular mass of 19.7 kDa.

Introduction: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Product Categories/Family for sRANKL active protein

Cytokines and Growth Factors; Growth Factors; RANK Ligand

NCBI and Uniprot Product Information

• NCBI GI #: 4507595
• NCBI GeneID: 8600
• NCBI Accession #: NP_003692.1
• NCBI GenBank Nucleotide #: NM_003701.3
• UniProt Accession #: O14788; O14723; Q96Q17; Q9P2Q3
• Molecular Weight: 30,523 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 11 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 11
• NCBI Official Symbol: TNFSF11
• NCBI Official Synonym Symbols: ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 11; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 11
• UniProt Gene Name: TNFSF11
• UniProt Synonym Gene Names: OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE
• UniProt Entry Name: TNF11_HUMAN