SDS-PAGE
(Recombinant Estrogen Receptor-alpha protein gel 9% SDS-PAGE gel with Coomassie blue staining MW: 67.5 kDa Purity: >80%)
Estrogen Receptor a Recombinant Protein | ESR1 recombinant protein
Recombinant Estrogen Receptor a protein
Gene Names
ESR1; ER; ESR; Era; ESRA; NR3A1
Synonyms
Estrogen Receptor a; N/A; Recombinant Estrogen Receptor a protein; ESR1; NR3A1; ESR1 recombinant protein
Host
Baculovirus
Form/Format
Recombinant Estrogen Receptor-alpha protein is supplied in 25mMHEPES-NaOH pH7.5, 300mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5mM TCEP.
Concentration
0.25ug/ul (varies by lot)
Protein Species
Human
Tag
N-terminal DYKDDDDK Tag
Notes
This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for this product is shown.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
Shipping Temp: Dry Ice
SDS-PAGE
(Recombinant Estrogen Receptor-alpha protein gel 9% SDS-PAGE gel with Coomassie blue staining MW: 67.5 kDa Purity: >80%)
SDS-PAGE
(Recombinant Estrogen Receptor-alpha protein gel 9% SDS-PAGE gel with Coomassie blue staining MW: 67.5 kDa Purity: >80%)
Related Product Information for ESR1 recombinant protein
Short Description: Recombinant Estrogen Receptor-alpha protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_000116.2) with an N-terminal DYKDDDDK tag. The molecular weight of the protein is 67.5 kDa.
Background: Estrogen Receptor-alpha protein, also called as ESRA or ER-alpha, is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. ER-alpha can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. It also mediates membrane-initiated estrogen signaling involving various kinase cascades.
Background: Estrogen Receptor-alpha protein, also called as ESRA or ER-alpha, is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. ER-alpha can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. It also mediates membrane-initiated estrogen signaling involving various kinase cascades.
Product Categories/Family for ESR1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
67.5 kDa
NCBI Official Full Name
estrogen receptor
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Official Symbol
ESR1
NCBI Official Synonym Symbols
ER; ESR; Era; ESRA; NR3A1
NCBI Protein Information
estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen
UniProt Protein Name
Estrogen receptor
UniProt Gene Name
ESR1
UniProt Synonym Gene Names
ESR; NR3A1; ER
UniProt Entry Name
ESR1_HUMAN
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Product Notes
The ESR1 esr1 (Catalog #AAA60203) is a Recombinant Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Estrogen Receptor a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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