GAS6 recombinant protein

Recombinant Human GAS6 Protein (His Tag), HPLC-verified

Cat. Num. AAA259290

• Gene Names: GAS6; AXSF; AXLLG
• Reactivity: Human
• Purity: >= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
• Synonyms: GAS6; N/A; Recombinant Human GAS6 Protein (His Tag), HPLC-verified; Human GAS6 Protein (His Tag); growth arrest-specific 6; AXLLG Protein, Human; AXSF Protein, Human; DKFZp666G247 Protein, Human; FLJ34709 Protein, Human; GAS6 recombinant protein

• Host: HEK293 Cells
• Reactivity: Human
• Purity/Purification: >= 95% as determined by SDS-PAGE. >= 90% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence: Ala49-Ala678

• Tag: C-His
• Predicted N Terminal: Ala 49
• Endotoxin: < 1.0 EU perug of the protein as determined by the LAL method
• Protein Construction: A DNA sequence encoding the Human GAS6 (NP_000811.1)(Ala49-Ala678) was expressed with a polyhistidine tag at the C-terminus.
• Activity: Immobilized Recombinant Human AXL Protein (Fc Tag) at 2ug/mL (100uL/well) can bind Recombinant Human GAS6 Protein (His Tag), the EC50 is 4-15ng/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Application Data

(Immobilized Recombinant Human AXL Protein (Fc Tag) at 2ug/mL (100uL/well) can bind Recombinant Human GAS6 Protein (His Tag)(#AAA259290), the EC50 is 4-15ng/mL.)

Application Data

Application Data

Related Product Information for GAS6 recombinant protein

The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. GAS6, expressed by osteoblasts in the bone marrow, plays a significant role in the regulation of PCa cell survival during chemotherapy, which will have important implications for targeting metastatic disease. The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. It had been show that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells, and GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy.

NCBI and Uniprot Product Information

• NCBI GI #: 4557617
• NCBI GeneID: 2621
• NCBI Accession #: NP_000811.1
• NCBI GenBank Nucleotide #: NM_000820.2
• UniProt Accession #: Q14393; Q6IMN1; Q7Z7N3; B3KRQ7; B3KVL4; E9PBL7
• Molecular Weight: 79,677 Da
• NCBI Official Full Name: growth arrest-specific protein 6 isoform 1
• NCBI Official Synonym Full Names: growth arrest-specific 6
• NCBI Official Symbol: GAS6
• NCBI Official Synonym Symbols: AXSF; AXLLG
• NCBI Protein Information: growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand
• UniProt Protein Name: Growth arrest-specific protein 6
• UniProt Gene Name: GAS6
• UniProt Synonym Gene Names: AXLLG; GAS-6
• UniProt Entry Name: GAS6_HUMAN