IHC (Immunohiostchemistry)
(DCTN1 staining (dilution: 1ug/ml) of Human Testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Goat anti-Human Dynactin 1 Antibody | anti-DCTN1 antibody
Dynactin 1
Gene Names
DCTN1; P135; DP-150; DAP-150
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Affinity Purified
Synonyms
Dynactin 1; N/A; anti-DCTN1 antibody
Host
Goat
Reactivity
Human
Isotype
IgG
Purity/Purification
Affinity Purified
Form/Format
Liquid
Sequence Length
1278
Applicable Applications for anti-DCTN1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
Synthetic peptide: C-QEQLHQLHSRLIS, from the C Terminus of the protein sequence according to NP_004073.2; NP_075408.1; NP_001128512.1; NP_001128513.1.
IHC (Immunohiostchemistry)
(DCTN1 staining (dilution: 1ug/ml) of Human Testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
IHC (Immunohiostchemistry)
(DCTN1 staining (dilution: 1ug/ml) of Human Testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
IHC (Immunohistochemistry)
(DCTN1 staining (dilution: 2.5ug/ml) staining of human brain tissue, cortex (formalin-fixed paraffin-embedded) followed by biotinylated horse anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.)
IHC (Immunohistochemistry)
(DCTN1 staining (dilution: 2.5ug/ml) staining of human brain tissue, cortex (formalin-fixed paraffin-embedded) followed by biotinylated horse anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet.)
Related Product Information for anti-DCTN1 antibody
This gene encodes the largest subunit of dynactin (DCTN), a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one.
Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy. Defects in DCTN1 are the cause of Perry syndrome (PERRYS) also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss.
Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy. Defects in DCTN1 are the cause of Perry syndrome (PERRYS) also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Dynactin subunit 1
NCBI Official Synonym Full Names
dynactin subunit 1
NCBI Official Symbol
DCTN1
NCBI Official Synonym Symbols
P135; DP-150; DAP-150
NCBI Protein Information
dynactin subunit 1
UniProt Protein Name
Dynactin subunit 1
UniProt Gene Name
DCTN1
UniProt Synonym Gene Names
DP-150
UniProt Entry Name
DCTN1_HUMAN
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Product Notes
The DCTN1 dctn1 (Catalog #AAA76597) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Dynactin 1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Dynactin 1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the DCTN1 dctn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Dynactin 1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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