Programmed Cell Death 1 Ligand 1 Active Protein | Cd274 active protein

Recombinant Mouse Programmed Cell Death 1 Ligand 1 Protein

Cat. Num. AAA174604

• Gene Names: Cd274; B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Programmed Cell Death 1 Ligand 1; N/A; Recombinant Mouse Programmed Cell Death 1 Ligand 1 Protein; Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274; Cd274 active protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 290

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Sequence: Phe19-Thr238
• Tag: C-His
• Bio-activity: Immobilized Anti-Human PDL1 mAb-Fc at 2 ug/ml (100 ul/well)can bind Mouse PD-L1-His. The ED50 of Mouse PD-L1-His is 23.35 ng/ml.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C.; Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

WB (Western Blot)

Related Product Information for Cd274 active protein

Mouse Programmed cell death 1 ligand 1(Cd274,PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

NCBI and Uniprot Product Information

• NCBI GI #: 11230798
• NCBI GeneID: 60533
• NCBI Accession #: NP_068693.1
• NCBI GenBank Nucleotide #: NM_021893.3
• UniProt Accession #: Q9EP73
• Molecular Weight: Molecular Mass: 25.6kDa ; Actual Protein Molecular Mass: 39-58kDa
• NCBI Official Full Name: programmed cell death 1 ligand 1
• NCBI Official Synonym Full Names: CD274 antigen
• NCBI Official Symbol: Cd274
• NCBI Official Synonym Symbols: B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
• NCBI Protein Information: programmed cell death 1 ligand 1
• UniProt Protein Name: Programmed cell death 1 ligand 1
• UniProt Gene Name: Cd274
• UniProt Synonym Gene Names: B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1