DR6 Active Protein | TNFRSF21 active protein

DR6 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA257839

• Gene Names: TNFRSF21; DR6; CD358; BM-018
• Purity: >96% as determined by SDS-PAGE
• Synonyms: DR6; N/A; DR6 Protein, Human, Recombinant (His Tag); Human DR6/TNFRSF21 Protein (His Tag); BM-018 Protein, Human; CD358 Protein, Human; DR6 Protein, Human; tumor necrosis factor receptor superfamily, member 21; TNFRSF21 active protein

• Host: HEK293 Cells
• Purity/Purification: >96% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.5. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Leu350

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 42
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain (Met 1-Leu 350) of human DR6 (NP_055267.1) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Activity: 1. Measured by its binding ability in a functional ELISA.; 2. Immobilized recombinant human DR6-his at 10ug/mL (100uL/well) can bind biotinylated human APP-Fc with a linear range of 0.0125-0.4ug/mL.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

Application Data

(Measured by its binding ability in a functional ELISA. Immobilized recombinant human DR6-his at 10 ug/mL (100 ul/well) can bind biotinylated human APP-Fc with a linear range of 0.0125-0.4 ug/mL.)

SDS-PAGE

Related Product Information for TNFRSF21 active protein

Background: TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

Product Categories/Family for TNFRSF21 active protein

Death Receptor Signaling

References

Pan G, et al. (1998) Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett. 431(3): 351-6.Benschop R, et al. (2009) Tumor necrosis factor receptor superfamily member 21: TNFR-related death receptor-6, DR6. Adv Exp Med Biol. 647: 186-94.Klma M, et al. (2009) Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta. 1793(10): 1579-87.

NCBI and Uniprot Product Information

• NCBI GI #: 7657039
• NCBI GeneID: 27242
• NCBI Accession #: NP_055267.1
• NCBI GenBank Nucleotide #: NM_014452.4
• UniProt Accession #: O75509; Q0D2P5; Q96D86; B2RDI9
• Molecular Weight: 71,845 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 21
• NCBI Official Synonym Full Names: TNF receptor superfamily member 21
• NCBI Official Symbol: TNFRSF21
• NCBI Official Synonym Symbols: DR6; CD358; BM-018
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 21
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 21
• UniProt Gene Name: TNFRSF21
• UniProt Synonym Gene Names: DR6
• UniProt Entry Name: TNR21_HUMAN