Fc epsilon RI alpha Active Protein | FcepsilonRIalpha active protein

Recombinant Human Fc epsilon RI alpha protein

Cat. Num. AAA48987

• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: Fc epsilon RI alpha; N/A; Recombinant Human Fc epsilon RI alpha protein; High affinity immunoglobulin epsilon receptor subunit alpha isoform1; FCERIA; FCERA; Fc epsilon receptor Ia; Fc-epsilon RI-alpha; Fc epsilon RI alpha chain; FcERI; IgE Fc receptor subunit alpha; FCER1A; FCE1A; FcepsilonRIalpha active protein

• Host: HEK293
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 1mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence Positions: 26-205aa
• Sequence: Val 26; VPQKPKVSLN PPWNRIFKGE NVTLTCNGNN FFEVSSTKWF HNGSLSEETN SSLNIVNAKF EDSGEYKCQH QQVNESEPVY LEVFSDWLLL QASAEVVMEG QPLFLRCHGW RNWDVYKVIY YKDGEALKYW YENHNISITN ATVEDSGTYY CTGKVWQLDY ESEPLNITVI KAPREKYWLQ

• Applicable Applications for FcepsilonRIalpha active protein: Bioactivity, SDS-PAGE
• Species: Human
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Tag: His-Tag
• Preparation and Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Related Product Information for FcepsilonRIalpha active protein

Fc epsilon RI alpha, also known as FCER1A, is an IgE?binding protein of the multichain immune recognition family. Fc epsilon receptor is a tetrameric complex of one alpha, one beta and two gamma subunits on mast cells and basophils. This protein represents the alpha subunit, only the alpha subunit is glycosylated. The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes—potent effectors of the hypersensitivity response. Recombinant human Fc epsilon RI alpha/FCER1A, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Categories/Family for FcepsilonRIalpha active protein

Immunology; Proteins

References

ZHANG,Y., et al. (2012) Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 47 (4), 289-293.
Zhou,J., et al. (2012) Hum. Immunol. 73 (3), 301-305.
D Maurer., et al. (1996) J Immunol. 157(2),607-616.

NCBI and Uniprot Product Information

• UniProt Accession #: P12319
• Molecular Weight: 21.8kDa (186aa)
• UniProt Protein Name: High affinity immunoglobulin epsilon receptor subunit alpha
• UniProt Gene Name: FCER1A
• UniProt Synonym Gene Names: FCE1A; FcERI
• UniProt Entry Name: FCERA_HUMAN