Human HA Antibody | anti-HA antibody
Anti-HA [CR6261], Human IgG1
Reactivity
Influenza A virus (several subtypes)
Applications
Neutralization Assay
Purity
Protein A affinity purified
Synonyms
HA; N/A; Anti-HA [CR6261], Human IgG1; Anti-HA [CR6261]; Hemagglutinin; Avian Influenza Virus; AIV; H1N1; H5N1; Influenza A virus; anti-HA antibody
Host
Human
Reactivity
Influenza A virus (several subtypes)
Isotype
Human IgG1, Kappa
Clone Number
CR6261
Specificity
This antibody binds hemaglutinin of most group 1 influenza viruses. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1/HA2.
Purity/Purification
Protein A affinity purified
Form/Format
PBS with 0.02% Proclin 300.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-HA antibody
NTRL (Neutralization)
Immunogen
The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza.
Preparation and Storage
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Related Product Information for anti-HA antibody
The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection (PMID: 19251591). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR6261 (PMID: 22693576).
References
Throsby et al. Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells. PLoS One. (2008); 3(12): e3942. PMID:19079604
NCBI and Uniprot Product Information
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Product Notes
The HA ha (Catalog #AAA72278) is an Antibody produced from Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-HA [CR6261], Human IgG1 reacts with Influenza A virus (several subtypes) and may cross-react with other species as described in the data sheet. AAA Biotech's HA can be used in a range of immunoassay formats including, but not limited to, NTRL (Neutralization). Researchers should empirically determine the suitability of the HA ha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HA, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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