SDS-PAGE
ADAM15 / MDC15 active protein
Recombinant Mouse ADAM15 / MDC15 Protein (His tag)
Gene Names
Adam15; AD56; MDC15
Purity
> 90 % as determined by SDS-PAGE
Synonyms
ADAM15 / MDC15; N/A; Recombinant Mouse ADAM15 / MDC15 Protein (His tag); MDC15, metargidin; ADAM15 / MDC15 active protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% Tween80.
Sequence Length
864
Source
Mouse
Predicted N Terminal
Arg 18 & Asp 208
Endotoxin
< 1.0 EU per ug of the protein as determined by the LAL method
Bio-Activity
1. Measured by its ability to bind human PTK6 in a functional ELISA.
2. Measured by its ability to bind human SRC in a functional ELISA.
3. Measured by its ability to bind mouse SRC in a functional ELISA.
4. Measured by its ability to bind human LYN in a functional ELISA.
2. Measured by its ability to bind human SRC in a functional ELISA.
3. Measured by its ability to bind mouse SRC in a functional ELISA.
4. Measured by its ability to bind human LYN in a functional ELISA.
Reconstitute
It is recommended that sterile water (80 ul) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV-Vis.
Concentration is measured by UV-Vis.
Preparation and Storage
tore it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
SDS-PAGE
SDS-PAGE
Related Product Information for ADAM15 / MDC15 active protein
Background: ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell type s. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.
Description: A DNA sequence encoding the mouse ADAM15 (O88839-1) extracellular domain (Met 1-Thr 697) was expressed, with a C-terminal polyhistidine tag.
Description: A DNA sequence encoding the mouse ADAM15 (O88839-1) extracellular domain (Met 1-Thr 697) was expressed, with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
48,417 Da
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein
NCBI Official Synonym Full Names
a disintegrin and metallopeptidase domain 15 (metargidin)
NCBI Official Symbol
Adam15
NCBI Official Synonym Symbols
AD56; MDC15
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 15
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 15
UniProt Gene Name
Adam15
UniProt Synonym Gene Names
Mdc15; ADAM 15; MDC-15
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Product Notes
The ADAM15 / MDC15 adam15 (Catalog #AAA173583) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ADAM15 / MDC15, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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