Butyrylcholine Esterase Active Protein | BCHE active protein
Recombinant Human Butyrylcholine Esterase Protein
Gene Names
BCHE; E1; CHE1; CHE2; BCHED
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Butyrylcholine Esterase; N/A; Recombinant Human Butyrylcholine Esterase Protein; Cholinesterase; Acylcholine Acylhydrolase; Choline Esterase II; Pseudocholinesterase; BCHE; CHE1; BCHE active protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Liquid; Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
Sequence Length
602
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Sequence
Glu29-Leu602
Tag
C-6His
Activity
Measured by its ability to cleave Butyrylthiocholine. The specific activity is >50,000 pmoles/min/mug.
Preparation and Storage
Upon receipt, immediately store at < -20°C, stable for 6 months.
Please minimize freeze-thaw cycles.
Please minimize freeze-thaw cycles.
Related Product Information for BCHE active protein
Protein Construction: Recombinant Human Butyrylcholine Esterase is produced by our Mammalian expression system and the target gene encoding Glu29-Leu602 is expressed with a 6His tag at the C-terminus.
Background: Butyrylcholine Esterase (BCHE) is a secreted protein that belongs to the type-B carboxylesterase/lipase family. BCHE is a major acetylcholine hydrolyzing enzyme in the circulation. It is detected in blood plasma and present in most cells except erythrocytes. BCHE is an esterase with broad substrate specificity. BCHE can contribute to the inactivation of the neurotransmitter acetylcholine. BCHE can degrade a large number of neurotoxic organophosphate esters. Thus, it plays important pharmacological and toxicological roles and is thought to be involved in the pathological progression. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) which is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine and other ester local anesthetics.
Background: Butyrylcholine Esterase (BCHE) is a secreted protein that belongs to the type-B carboxylesterase/lipase family. BCHE is a major acetylcholine hydrolyzing enzyme in the circulation. It is detected in blood plasma and present in most cells except erythrocytes. BCHE is an esterase with broad substrate specificity. BCHE can contribute to the inactivation of the neurotransmitter acetylcholine. BCHE can degrade a large number of neurotoxic organophosphate esters. Thus, it plays important pharmacological and toxicological roles and is thought to be involved in the pathological progression. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) which is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine and other ester local anesthetics.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 66.1kDa
Actual Protein Molecular Mass: 90kDa
Actual Protein Molecular Mass: 90kDa
NCBI Official Full Name
cholinesterase
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Symbol
BCHE
NCBI Official Synonym Symbols
E1; CHE1; CHE2; BCHED
NCBI Protein Information
cholinesterase
UniProt Protein Name
Cholinesterase
UniProt Gene Name
BCHE
UniProt Synonym Gene Names
CHE1
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Product Notes
The BCHE bche (Catalog #AAA174587) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Butyrylcholine Esterase, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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