Application Data
(Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 5-20 ng/ml.)
IL-15 Receptor alpha & IL-15 Fusion Protein/IL15RA&IL15 Active Protein | IL15RA&IL15 active protein
Recombinant Human IL-15 Receptor alpha & IL-15 Fusion Protein/IL15RA&IL15 Protein (C-Fc)
Gene Names
IL15RA; CD215
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
IL-15 Receptor alpha & IL-15 Fusion Protein/IL15RA&IL15; N/A; Recombinant Human IL-15 Receptor alpha & IL-15 Fusion Protein/IL15RA&IL15 Protein (C-Fc); IL15RA&IL15; Interleukin-15; IL-15; IL15; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin-15 receptor subunit alpha; IL15RA&IL15 active protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered solution of PBS, 5% trehalose, pH 7.4.
Sequence Positions
Ile31-Asp96 & Asn49-Ser162
Sequence Length
231
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL method.
Tag
C-Fc
Reconstitution
We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water be added to the vial to prepare a stock solution of 100ug/mL. Concentration is measured by UV-Vis.
Preparation and Storage
Lyophilized protein should be stored at < -20°C, Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Application Data
(Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 5-20 ng/ml.)
Application Data
(Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is 5-20 ng/ml.)
SDS-PAGE
SDS-PAGE
Related Product Information for IL15RA&IL15 active protein
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 46.9 kDa
Actual Protein Molecular Mass: 50-60 kDa
Actual Protein Molecular Mass: 50-60 kDa
NCBI Official Full Name
interleukin-15 receptor subunit alpha isoform 3
NCBI Official Synonym Full Names
interleukin 15 receptor subunit alpha
NCBI Official Symbol
IL15RA
NCBI Official Synonym Symbols
CD215
NCBI Protein Information
interleukin-15 receptor subunit alpha
UniProt Protein Name
Interleukin-15 receptor subunit alpha
UniProt Gene Name
IL15RA
UniProt Synonym Gene Names
IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA
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Product Notes
The IL15RA&IL15 il15ra (Catalog #AAA22119) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Ile31-Asp96 & Asn49-Ser162. It is sometimes possible for the material contained within the vial of "IL-15 Receptor alpha & IL-15 Fusion Protein/IL15RA&IL15, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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