Application Data
Interleukin-4/IL-4 Active Protein | IL-4 active protein
Recombinant Human Interleukin-4/IL-4 Protein (Active)
Applications
Immunogen
Purity
> 95 % as determined by SDS-PAGE.
Synonyms
Interleukin-4/IL-4; N/A; Recombinant Human Interleukin-4/IL-4 Protein (Active); Interleukin-4; IL-4; B-Cell Stimulatory Factor 1; BSF-1; Binetrakin; Lymphocyte Stimulatory Factor 1; Pitrakinra; IL4; IL-4 active protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered solution of 20mM PBS, 150mM NaCl, pH 7.4.
Applicable Applications for IL-4 active protein
Immunogen
Biological Activity
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.01-0.05 ng/ml.
Endotoxin
< 1.0 EU per g as determined by the LAL method.
Preparation and Storage
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Application Data
Application Data
Bioactivity
Bioactivity
Related Product Information for IL-4 active protein
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
NCBI and Uniprot Product Information
UniProt Accession #
Molecular Weight
14.97 kDa
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Product Notes
The IL-4 (Catalog #AAA176986) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Interleukin-4/IL-4 can be used in a range of immunoassay formats including, but not limited to, Immunogen. Researchers should empirically determine the suitability of the IL-4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin-4/IL-4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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