Signal Transducer CD24/CD24 Active Protein | CD24/CD24 active protein

Recombinant Human Signal Transducer CD24/CD24 (C-Fc)

Cat. Num. AAA177955

• Gene Names: CD24; CD24A
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Signal Transducer CD24/CD24; N/A; Recombinant Human Signal Transducer CD24/CD24 (C-Fc); Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A ; CD24/CD24 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Ser27-Gly59

• Species: Human
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly 59 is expressed with a Fc tag at the C-terminus.
• Activity: Immobilized Anti-Human CD24 mAb at 2ug/ml (100ul/well) can bind Human CD24-Fc* *: Biotinylated by NHS-biotin prior to testing.The ED50 of Human CD24-Fc* is 7.62ng/ml.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

Bioactivity

SDS-PAGE

Related Product Information for CD24/CD24 active protein

Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

Product Categories/Family for CD24/CD24 active protein

Neuroscience; Cancer; immunology; metabolism; Stem cells

NCBI and Uniprot Product Information

• NCBI GI #: 143811372
• NCBI GeneID: 100133941
• UniProt Accession #: P25063; Q16257; Q53XS0
• Molecular Weight: 80
• NCBI Official Full Name: Signal transducer CD24
• NCBI Official Synonym Full Names: CD24 molecule
• NCBI Official Symbol: CD24
• NCBI Official Synonym Symbols: CD24A
• NCBI Protein Information: signal transducer CD24; CD24 antigen (small cell lung carcinoma cluster 4 antigen)
• UniProt Protein Name: Signal transducer CD24
• UniProt Gene Name: CD24
• UniProt Synonym Gene Names: CD24A
• UniProt Entry Name: CD24_HUMAN