Application Data
(This assay recognizes both recombinant and natural Human IL18R1. The factors listed above were prepared at 10 or 50ng/mL in dilution buffer and assayed for cross-reactivity. No cross -reactivity was observed.Preparations of IL18 prepared at 5ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.)
Human IL18R1 ELISA Kit | IL18R1 elisa kit
Human IL18R1 ELISA Kit
Reactivity
Human
Synonyms
IL18R1; N/A; Human IL18R1 ELISA Kit; IL-18Ralpha ELISA Kit, Human; interleukin 18 receptor 1; CD218a ELISA Kit, Human; CDw218a ELISA Kit, Human; IL-1Rrp ELISA Kit, Human; IL18RA ELISA Kit, Human; IL1RRP ELISA Kit, Human; IL18R1 elisa kit
Reactivity
Human
Specificity
For the quantitative determination of Human IL18R1 concentration in serum.
Assay Type
Solid Phase Sandwich ELISA (quantitative)
Sample Types
Serum
Detection Range
7.81-500pg/mL
Sensitivity
3.49pg/mL
Conjugation
HRP
Interference
Preparations of IL18 prepared at 5ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.
Materials Provided
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
Application Data
(This assay recognizes both recombinant and natural Human IL18R1. The factors listed above were prepared at 10 or 50ng/mL in dilution buffer and assayed for cross-reactivity. No cross -reactivity was observed.Preparations of IL18 prepared at 5ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.)
Application Data
(This assay recognizes both recombinant and natural Human IL18R1. The factors listed above were prepared at 10 or 50ng/mL in dilution buffer and assayed for cross-reactivity. No cross -reactivity was observed.Preparations of IL18 prepared at 5ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.)
Standard Curve (Sample)
(This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.)
Standard Curve (Sample)
(This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.)
Related Product Information for IL18R1 elisa kit
This IL-18Ralpha ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IL-18Ralpha protein in Serum. It contains recombinant Human IL-18Ralpha, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
Background: Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
Background: Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
References
Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
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Product Notes
The Human IL18R1 (Catalog #AAA258421) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA258421 ELISA Kit recognizes Human IL18R1. It is sometimes possible for the material contained within the vial of "IL18R1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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