Standard Curve (Sample)
(Typical Testing Data/Standard Curve (for reference only))
Human Ribonucleoside-Diphosphate Reductase Subunit M2 B, RRM2B ELISA Kit | RRM2B elisa kit
Human Ribonucleoside-Diphosphate Reductase Subunit M2 B, RRM2B Primacu ELISA Kit
Gene Names
RRM2B; P53R2; MTDPS8A; MTDPS8B
Reactivity
Human
Synonyms
Ribonucleoside-Diphosphate Reductase Subunit M2 B, RRM2B; N/A; Human Ribonucleoside-Diphosphate Reductase Subunit M2 B, RRM2B Primacu ELISA Kit; Ribonucleoside-diphosphate reductase subunit M2 B; p53R2; P53R2; RRM2B elisa kit
Reactivity
Human
Assay Type
Sandwich
Samples
Serum, plasma, cell culture supernates
Detection Range
46.88-3000pg/mL
Sensitivity
14.93pg/mL
Standard Solution
30ng/mL
Assay Time
3.5h
Preparation and Storage
Store at 2-8 degree C
Standard Curve (Sample)
(Typical Testing Data/Standard Curve (for reference only))
Standard Curve (Sample)
(Typical Testing Data/Standard Curve (for reference only))
Related Product Information for RRM2B elisa kit
Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phosphorylated protein. It is hypothesized that RRM2B activity can be regulated at the posttranslational level in response to DNA damage. RRM2B has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of RRM2B to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of RRM2B posttranslationally. Besides, a defect in RRM2B can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic.
Product Categories/Family for RRM2B elisa kit
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,737 Da
NCBI Official Full Name
ribonucleoside-diphosphate reductase subunit M2 B isoform 2
NCBI Official Synonym Full Names
ribonucleotide reductase M2 B (TP53 inducible)
NCBI Official Symbol
RRM2B
NCBI Official Synonym Symbols
P53R2; MTDPS8A; MTDPS8B
NCBI Protein Information
ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53-inducible ribonucleot
UniProt Protein Name
Ribonucleoside-diphosphate reductase subunit M2 B
UniProt Gene Name
RRM2B
UniProt Synonym Gene Names
P53R2; p53R2
UniProt Entry Name
RIR2B_HUMAN
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Product Notes
The Human RRM2B rrm2b (Catalog #AAA124216) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA124216 ELISA Kit recognizes Human RRM2B. It is sometimes possible for the material contained within the vial of "Ribonucleoside-Diphosphate Reductase Subunit M2 B, RRM2B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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