Insulin Receptor Recombinant Protein | INSR recombinant protein

Recombinant Mouse Insulin Receptor Protein (ECD, His Tag), HPLC-verified

Cat. Num. AAA259388

• Gene Names: Insr; IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
• Reactivity: Mouse
• Purity: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
• Synonyms: Insulin Receptor; N/A; Recombinant Mouse Insulin Receptor Protein (ECD, His Tag), HPLC-verified; Mouse Insulin Receptor Protein (ECD, His Tag); insulin receptor; 4932439J01Rik Protein, Mouse; CD220 Protein, Mouse; D630014A15Rik Protein, Mouse; Insr Protein, Mouse; IR Protein, Mouse; IR-A Protein, Mouse; IR-B Protein, Mouse; INSR recombinant protein

• Host: HEK293 Cells
• Reactivity: Mouse
• Purity/Purification: >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
• Form/Format: Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence: Met1-Lys946

• Tag: C-His
• Predicted N Terminal: His 28
• Endotoxin: < 1.0 EU perug of the protein as determined by the LAL method
• Protein Construction: A DNA sequence encoding the Mouse INSR (NP_034698.2)(Met1-Lys946) was expressed with a polyhistidine tag at the C-terminus.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Application Data

Application Data

Related Product Information for INSR recombinant protein

INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).

Product Categories/Family for INSR recombinant protein

AMPK Signaling Pathway; Receptor Tyrosine Kinases (RTKs)

References

Ebin. Y.. e. al.,(1985). Th. huma. insuli. recepto. cDNA. th. structura. basi. fo. hormone-activate. transmembran. signalling. Cel. 40:747-758.Ullric. A.. e. al.. (1985). Huma. insuli. recepto. an. it. relationshi. t. th. tyrosin. kinas. famil. o. oncogenes.Natur. 313:756-761.Grimwoo. J.. e. al.,(2004). Th. DN. sequenc. an. biolog. o. huma. chromosom. 19.Natur. 428:529-535.

NCBI and Uniprot Product Information

• NCBI GI #: 157057178
• NCBI GeneID: 16337
• NCBI Accession #: NP_034698.2
• NCBI GenBank Nucleotide #: NM_010568.2
• UniProt Accession #: P15208; F8VPU4
• Molecular Weight: 155,610 Da
• NCBI Official Full Name: insulin receptor
• NCBI Official Synonym Full Names: insulin receptor
• NCBI Official Symbol: Insr
• NCBI Official Synonym Symbols: IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik
• NCBI Protein Information: insulin receptor
• UniProt Protein Name: Insulin receptor
• UniProt Gene Name: Insr
• UniProt Synonym Gene Names: IR
• UniProt Entry Name: INSR_MOUSE