Application Data
KAT2A recombinant protein
KAT2A (GCN5), Active
Gene Names
KAT2A; GCN5; hGCN5; GCN5L2; PCAF-b
Synonyms
KAT2A; N/A; KAT2A (GCN5), Active; KAT2A recombinant protein
Host
Sf9 insect cells using baculovirus
Form/Format
50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Sequence Positions
323-end
Sequence Length
3127
Species
Human
Tag
GST tag
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store product at -70 degree C.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Application Data
Application Data
Application Data
Application Data
Related Product Information for KAT2A recombinant protein
Description: Recombinant human KAT2A (GCN5) (323-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: KAT2A (K (lysine) acetyltransferase 2A) is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator which functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner (1). KAT2A control chromosome stability by coordinating the ATR checkpoint and double-strand break processing with autophagy. KAT2A acetyltransferases have homologous sequences and enzymatic activities which are important for recognition of nucleosomal substrates (2).
Scientific Background: KAT2A (K (lysine) acetyltransferase 2A) is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator which functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner (1). KAT2A control chromosome stability by coordinating the ATR checkpoint and double-strand break processing with autophagy. KAT2A acetyltransferases have homologous sequences and enzymatic activities which are important for recognition of nucleosomal substrates (2).
Product Categories/Family for KAT2A recombinant protein
References
1. Mao, X. et.al: GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappa-B/RelA. Genes Dev. 23: 849-861, 2009. 2. Xu, W. et.al: Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Molec. Cell. Biol. 18: 5659-5669, 1998.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~82 kDa
NCBI Official Full Name
Homo sapiens lysine acetyltransferase 2A (KAT2A), mRNA
NCBI Official Synonym Full Names
lysine acetyltransferase 2A
NCBI Official Symbol
KAT2A
NCBI Official Synonym Symbols
GCN5; hGCN5; GCN5L2; PCAF-b
NCBI Protein Information
histone acetyltransferase KAT2A
UniProt Protein Name
Histone acetyltransferase KAT2A
UniProt Gene Name
KAT2A
UniProt Synonym Gene Names
GCN5; GCN5L2; HGCN5; HsGCN5
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Product Notes
The KAT2A kat2a (Catalog #AAA72996) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 323-end. It is sometimes possible for the material contained within the vial of "KAT2A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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