SDS-PAGE
(The purity was determined to be >80% by densitometry.Approx. MW 95kDa)
LATS2 recombinant protein
LATS2, Unactive recombinant protein
Gene Names
LATS2; KPM
Applications
Western Blot
Purity
>80%
Synonyms
LATS2; N/A; LATS2, Unactive recombinant protein; KPM; FLJ13161; LATS2 recombinant protein
Host
Sf9 insect cells
Purity/Purification
>80%
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.2ug/ul (varies by lot)
Sequence Positions
480-1088
Sequence Length
5558
Applicable Applications for LATS2 recombinant protein
WB (Western Blot), Kinase Assay
Type
Recombinant Fusion Protein
Species
Human
Tag Information
GST tag
Expression System
Sf9 insect cells using baculovirus
Source Note
Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Stability: 1yr At –70oC from date of shipment
Storage & Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: ships on dry ice.
Storage & Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: ships on dry ice.
SDS-PAGE
(The purity was determined to be >80% by densitometry.Approx. MW 95kDa)
SDS-PAGE
(The purity was determined to be >80% by densitometry.Approx. MW 95kDa)
Related Product Information for LATS2 recombinant protein
Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family (1). The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis (2). LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.
Scientific Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family (1). The kinase activity and two conserved domains within LATS2 are responsible for the suppression of tumorigenicity and inhibition of cell growth. LATS2 negatively regulates the cell cycle by controlling G1/S and/or G2/M transition. LATS2 interacts with the centrosomal proteins AURORA A and Ajuba and is required for accumulation of γ-tubulin and spindle formation at the onset of mitosis (2). LATS2 also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. LATS2 can also function as a co-repressor of androgen-responsive gene expression.
Product Categories/Family for LATS2 recombinant protein
References
1. Li, Y. et al: Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene. 2003; 22(28):4398-405.
2. Yabuta, N. et al: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 63(2):263-70.
2. Yabuta, N. et al: Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 63(2):263-70.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~98 kDa
NCBI Official Full Name
Homo sapiens large tumor suppressor kinase 2 (LATS2), mRNA
NCBI Official Synonym Full Names
large tumor suppressor kinase 2
NCBI Official Symbol
LATS2
NCBI Official Synonym Symbols
KPM
NCBI Protein Information
serine/threonine-protein kinase LATS2; warts-like kinase; serine/threonine kinase KPM; large tumor suppressor homolog 2; serine/threonine-protein kinase kpm; LATS, large tumor suppressor, homolog 2; kinase phosphorylated during mitosis protein; LATS (large tumor suppressor, Drosophila) homolog 2
UniProt Protein Name
Serine/threonine-protein kinase LATS2
UniProt Gene Name
LATS2
UniProt Synonym Gene Names
KPM
UniProt Entry Name
LATS2_HUMAN
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Product Notes
The LATS2 lats2 (Catalog #AAA72892) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 480-1088 with tag GST tag!!Expression System||Sf9 insect cells using baculovirus!!Source Note||Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells. AAA Biotech's LATS2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), Kinase Assay. Researchers should empirically determine the suitability of the LATS2 lats2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LATS2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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