Application Data
(Immobilized Recombinant Human R-Spondin 1 / RSPO1 Protein (His Tag) ( Cat:11083-H08H) at 2ug/mL (100uL/well) can bind Recombinant Human LRP6 Protein (Fc Tag) (#AAA259190), the EC50 is 120-360 ng/mL.)
LRP-6 recombinant protein
LRP-6 Protein, Human, Recombinant (hFc Tag), HPLC-verified
Gene Names
LRP6; ADCAD2
Purity
>= 90% as determined by SDS-PAGE.= 90% as determined by SEC-HPLC.
Synonyms
LRP-6; N/A; LRP-6 Protein, Human, Recombinant (hFc Tag), HPLC-verified; LDL receptor related protein 6; ADCAD2 Protein, Human; LRP-6 recombinant protein
Host
HEK293 Cells
Purity/Purification
>= 90% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
= 90% as determined by SEC-HPLC.
Form/Format
Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Species
Human
Predicted N Terminal
Ala 20
Endotoxin
<1.0 EU per ug protein as determined by the LAL method.
Protein Construction
A DNA sequence encoding the Human LRP6 (O75581)(Met1-Pro630) was expressed with the Fc region of human IgG1 at the C-terminus.
Activity
Immobilized Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)(Cat:11083-H08H) at 2ug/mL (100uL/well) can bind Recombinant Human LRP6 Protein (Fc Tag) , the EC50 is 120-360 ng/mL.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Application Data
(Immobilized Recombinant Human R-Spondin 1 / RSPO1 Protein (His Tag) ( Cat:11083-H08H) at 2ug/mL (100uL/well) can bind Recombinant Human LRP6 Protein (Fc Tag) (#AAA259190), the EC50 is 120-360 ng/mL.)
Application Data
(Immobilized Recombinant Human R-Spondin 1 / RSPO1 Protein (His Tag) ( Cat:11083-H08H) at 2ug/mL (100uL/well) can bind Recombinant Human LRP6 Protein (Fc Tag) (#AAA259190), the EC50 is 120-360 ng/mL.)
Application Data
Application Data
Application Data
Application Data
Related Product Information for LRP-6 recombinant protein
Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in the development and progression of colorectal cancer. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein that has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
180,429 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 6
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 6
NCBI Official Symbol
LRP6
NCBI Official Synonym Symbols
ADCAD2
NCBI Protein Information
low-density lipoprotein receptor-related protein 6; LRP-6
UniProt Protein Name
Low-density lipoprotein receptor-related protein 6
UniProt Gene Name
LRP6
UniProt Synonym Gene Names
LRP-6
UniProt Entry Name
LRP6_HUMAN
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Product Notes
The LRP-6 lrp6 (Catalog #AAA259190) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LRP-6, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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